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KMID : 0360220090500081221
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 8 p.1221 ~ p.1225
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Effectiveness of Preoperative Intravitreal Bevacizumab Injections in Pars Plana Vitrectomy for Proliferative Diabetic Retinopathy
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Jeon Gang-Seok
Kim Ha-Kyoung
Han Jae-Ryong
Nam Woo-Ho
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Abstract
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Purpose: To evaluate the efficacy of preoperative intravitreal bevacizumab (Avastinⓡ; Genetech, San Francisco, CA, USA) injections of pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR).
Methods: Thirty patients (30 eyes) who underwent PPV for treatment of PDR and received a preoperative intravitreal bevacizumab injection of 1.25 mg were retrospectively analyzed. The study group (group 1, 30 patients, 30 eyes) was compared with a control group (group 2, 29 patients, 30 eyes and matched with the study group for preoperative parameters) who underwent PPV without preoperative intravitreal bevacizumab injection.
Results: In both groups, visual acuity improved but there was no statistical significance. Intraoperative vitreous hemorrhage occurred in 14 eyes (46.7%) from group 1 and 11 eyes (36.7%) from group 2. There was no statistical significance of intraoperative bleeding occurrence (p=0.3). Postoperative vitreous hemorrhage occurred in 4 eyes from group 1 and 14 eyes from group 2. The group 1 had a lower incidence of postoperative hemorrhage than group 2 (p=0.005).
Conclusions: Preoperative intravitreal bevacizumab injection appears effective in decreasing early postoperative vitreous hemorrhage and maybe technically helpful in PPV for PDR.
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KEYWORD
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Bevacizumab (Avastinⓡ), Pars Plana Vitrectomy, Proliferative diabetic retinopathy
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